At UC Irvine, shippers are directly responsible for
the correct packaging, labeling, documentation, and record retention,
for hazardous materials shipped by air, land, and sea. This
mean that if you package and offer to commercial carriers any materials
that pose radioactive, chemical, biological or physical hazards
you must be certified through successful completion of relevant
training on hazardous materials shipping. Additionally, anyone
who offers advice on packaging, labeling, and documentation for
hazardous materials shipping, must possess relevant training certification.
(Code of Federal Regulations (CFR) 49, Part 172-H).
Prior to shipping research equipment or materials
out of the United States, and to ensure timely and compliant shipping
of export controlled items, perform an export
control review. Violation of export controls regulations can
result in both civil and criminal penalties for the individual.
Shippers at UC Irvine
pass trainings to be certified for hazardous materials shipping.
To achieve certification to package and offer hazardous materials
to commercial carriers, you must complete the foundation course
described below and all "function-specific" trainings appropriate
for the hazardous materials you intend to ship.
course meets three (3) of the four (4) regulatory training requirements
and is a prerequisite to further hazardous materials training. This
course is available on-line through the UC Learning Center. Look
in the course catalog using keyword "Shipping".
series of courses train shippers to package, label, and document
shipments of specific materials. Function-specific courses
are developed for specific hazardous materials determined to
be shipped most often. EH&S continues adding online function-specific
courses to meet changing campus needs.
- Function-specific courses are available online through the UC Learning Center.
- Search the course catalog using keyword "Shipping".
- Look for the specific material you intend to ship.
- If you do not see an online function-specific training for
the hazardous material you ship, contact EH&S
for assistance at 949-824-6200.
Hazardous Materials Shipping FAQs
materials are articles or substances which are capable of posing an unreasonable
risk to health, safety, property or the environment when transported by
commercial carriers. Hazardous
materials include hazardous substances, hazardous wastes, marine pollutants,
elevated temperature materials, and materials which meet the criteria of one or
more of nine United Nations (UN) hazard classes.
A Material Safety Data Sheet (MSDS) indicates whether the material is
hazardous and provides the UN hazard classification.
Hazard classes are:
Solids; Substances Liable to Spontaneous Combustion; Substances Which, in
Contact with Water, Emit Flammable Gases
Substances and Organic Peroxides
and Infectious Substances
2. Examples of
dangerous goods shipped from UC Irvine that require documented training:
Dry ice is assigned UN hazard
- When minimal likelihood that pathogens are present, patient and animal samples and cell lines are not assigned
to a UN hazard class; however, they still must be packaged and labeled as "Exempt human or animal specimens" by a trained person.
- Non-infectious genetically modified
microorganisms (GMMOs) and genetically modified organisms (GMOs) which
are capable of altering animals, plants, or microbiological substances in a way
which is not normally the result of reproduction are assigned to UN hazard Class
9. Infectious GMMO/GMO are assigned to UN hazard Class 6.2.
gases in compressed gas cylinders are assigned to Class 2.
Formalin or gluteraldehyde
(<10% solution) preserved specimens are not regulated. Minimize amounts
per inner packaging, and use triple-pack to ship
> 0.002 gauss @ 7 feet is assigned to Class 9.
types of batteries (lithium; sodium; potassium hydroxide; wet-filled with
acid or alkali fluid) and battery-containing equipment/vehicles are considered
dangerous goods usually assigned to Class 9.
Hazardous residues in machinery returned for repair is Class 9.
All radioactive materials (Class 7) must be shipped by EH&S.
What are infectious substances?
Infectious substances are substances which are known or are
reasonably expected to contain pathogens. Pathogens
are defined as micro-organisms (including bacteria, viruses, rickettsiae,
parasites, fungi) and other agents such as prions, which can cause disease in
humans or animals. Infectious
substances are divided into two groups: Category
A and Category B.
Category A is
for an infectious substance which is transported in a form that, when exposure
to it occurs is capable of causing permanent disability, life-threatening or
fatal disease in otherwise healthy humans or animals.
Category B is
for an infectious substance which does not meet the criteria for inclusion in
When are genetically
modified organisms/micro-organisms (GMO/GMMO) considered hazardous materials?
The researcher must complete a hazard determination based on the GMO/GMMO’s ability to pose unreasonable risk to health, safety, property or the environment, if released accidentally from packaging. If infectious, the organism is shipped as Infectious Substance Class 6.2 Category A or Category B. If the organism is not infectious, the GMO/GMMO is shipped using Triple-Pack procedures for Miscellaneous Class 9. Follow the GMO/GMMO shipping procedures located on the Hazardous Materials Shipping webpage. GMO/GMMO cannot be shipped as Excepted Quantities or Exempt. An example of shipping a non-hazardous GMMO is the non-pathogenic modified e.Coli commonly used in recombinant DNA research.
are Exempt Human and Animal Specimens?
lab rat & mouse specimens with minimal likelihood that pathogens are
present. Minimal likelihood that pathogens are present is determined by the
shipper's professional judgment using the following basis: known
medical history; symptoms and
individual circumstances of the source, human or animal; endemic
If exempt, use Triple Pack to ship.
for shipping dangerous goods to a foreign country
for shipping dangerous goods within the United States
Proper packaging, labeling, and completion of dangerous goods paperwork; visit https://www.ehs.uci.edu/programs/dgoods/index.html.
licensing review. Go to: http://www.research.uci.edu/ora/exportcontrol/index.htm
and complete the "Request
a Review of Shipments (doc)", or click
for instructions on performing an “Export Control Review before an
Invoice for the foreign customs agent. By
using e-Ship, the commercial invoice form will be generated.
A blank form is available from your international commercial carrier.
shipping research material developed by UC Irvine researchers including
biological materials, a Materials Transfer Agreement is needed.
Go to: http://www.ota.uci.edu/fac_material.htm.
country specific importation permits. The
receiver of the package is in the best position to obtain these when needed,
or a freight-forwarder or customs-broker knowledgeable in the destination
country. Examples of when permits may be needed are when shipping Class
6.2 Infectious Substances, live animals (contact ULAR),
packaging, labeling, and completion of dangerous goods paperwork; visit https://www.ehs.uci.edu/programs/dgoods/index.html.
shipping research material developed by UC Irvine researchers, including
biological materials, a Materials Transfer Agreement is needed.
Go to: http://www.ota.uci.edu/fac_material.htm.
Commercial Invoices are generated by the shipper to declare
the monetary value of exported goods. The
declared value is used by foreign customs agents to assess monetary duties that
need to be paid before the package clears customs.
When you use e-Ship to generate your airway bill to an international
destination, the Commercial Invoice is generated and is included in the
documentation sent with the package. It
is common that a small quantity of research material sent to foreign colleague
has neglible monetary value.
What is a Shipper's Declaration of Dangerous Goods?
Shipper's Declaration or "Shipper's Dec" is a document
completed and signed by a certified trained shipper. It is a
declaration by the shipper that the hazardous material has been packaged
according to regulations. It must be printed in color and has a
red hash mark border. Regulations require that the form is
completed in triplicate and the three copies accompany the package
during transportation. Note: FedEx requires four copies. A
copy of each Shipper's Declaration must be maintained by the shipper for
24 months. Any packages requiring a Shipper's Declaration must be
coordinated through EH&S or Physical Sciences Shipping &
Receiving--if in that school--in order to have copies of Shipper's
Declarations available for DOT and FAA inspectors. Shippers must use FedEx Ship Manager Software to generate the shipper Declaration.
How do I ship live animals?
is very important that University Laboratory Animal Resources (ULAR)
staff facilitate this type of shipment. Visit http://apps.research.uci.edu/ular/uci/transfers.cfm?
for up-to-date live animal shipping procedures.
What is "De minimis exception"?
minimis exception applies to shipments within the United States of Packaging Group II and III materials in Class
3, Division 4.1, Division 4.2, Division 4.3, Division 5.1, Division 6.1,
Class 8, and Class 9, for inner packaging maximum quantities of 1 mL or
1 g, and maximum outer packaging maximum quantities of 100 mL or 100
g. Pack items using the drop and compression tested triple-pack.
No hazard labels, markings, declarations are required. For air
transport, the material must be approved for passenger-carrying aircraft
(see Column 9A of DOT
Hazardous Materials Table), and de minimis quantities cannot
be carried in checked or carry-on baggage. The shipping company
must accept packages under DOT regulations.
What are "excepted quantities"?
quantities are small quantities of hazardous materials ranging from 1 mL
(g) to 30 mL (g) depending on the materials hazard level. You need
to know how to use the material's E-code, triple-pack, and special
package markings, so you need to pass function-specific
training for certification to ship excepted quantities.
What is triple-pack?
is tested packaging suitable for shipping de minimus, excepted, and
limited quantity hazardous materials. The 1st layer in the
triple-pack is the primary sample container known as the inner
packaging. It must be leak proof and chemically compatible
with the material, and its closure held securely in place with tape or
other positive means. Cushion multiple inner packagings from
touching each other and place them inside the intermediate packaging
(the 2nd layer) like sealable leak proof plastic bag or canister with
enough absorbent materials to completely absorb the entire contents of
the inner packages. Place the sealed plastic bag in a sturdy,
damage-free outer cardboard box, aka the outer packaging (the 3rd
layer). Use crumpled paper or other space filler to fill voids
between the intermediate packaging and outer packaging to block the
intermediate package from moving around. The triple-pack has been
compressive load and drop-tested from 7 feet to withstand the normal
conditions and stresses of transport.
How do I ship radioactive materials?
handles all radioactive materials shipments. Contact EH&S at
(949) 824-6200 and ask for a Radioactive Materials Shipping Specialist.
Who can I call for
assistance with shipping hazardous materials?
- Call (949) 824-6200, for referral to a Hazardous Materials Shipping Specialist.
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